Robbie Keane and James Tomkins have withdrawn from international duty with the Republic of Ireland and England Under-21 squads respectively with suspected calf injuries - while Robert Green and Carlton Cole have been added to the senior England party.
Keane's absence after he was substituted in Sunday's 1-0 defeat by Birmingham City was confirmed by Ireland manager Giovanni Trapattoni on Sunday evening, meaning the striker will play no part against Wales in Dublin on Tuesday. "It is a pity for Robbie because this game was an opportunity for him to continue playing after joining West Ham last week," he said. "We hope he recovers quickly."
Centre-back Tomkins was hurt in the warm-up before the Birmingham fixture. The club's medical staff notified the Football Association of his injury and his absence from the international friendly in Italy on Tuesday was confirmed later that evening.
Danny Gabbidon had already withdrawn from Wales duty to face the Irish, having suffered a hamstring injury against Blackpool in midweek.
Elsewhere, Green and Cole could play alongside Scott Parker against Lars Jacobsen when England travel to take on Denmark in Copenhagen on Wednesday. Green and Cole were called up on Sunday night after Ben Foster and Peter Crouch withdrew with injuries, while Parker's hopes of playing were raised when Steven Gerrard also pulled out.
The same day, Pablo Barrera's Mexico face Bosnia-Herzegovina in the American city of Atlanta, while Victor Obinna could line up for Nigeria against Sierra Leone in Lagos and Marek Stech has been included in the Czech Republic U21 squad for an international friendly with Netherlands in Waalwijk..
Tuesday will also see Academy midfielder Eoin Wearen turn out for Republic of Ireland U19s against Croatia in Zagreb, while his compatriot Kieran Sadlier will represent the Irish U17s in two friendlies against Italy in Lecce on 8 and 10 February.
Looking further forward, Matthias Fanimo and Blair Turgott are both in England's U17 squad for the Algarve Tournament, which will see the Young Lions take on Romania, Germany and hosts Portugal at the end of this month.
The U17s will use the tournament as preparation for their UEFA European U17 Championship Elite Round qualifiers at the end of March, where they have been drawn to face Northern Ireland, Spain and mini-group hosts Belgium.
Defending champions England won the European U17 title last summer, with West Ham's Robert Hall a member of the winning squad.
Finally, Leo Chambers has been named in England's U16 squad for a friendly international meeting with Slovenia in Koper on Tuesday 15 February.