As many as eleven West Ham United players could pull on their respective national team jerseys on Wednesday evening.
US defender Jonathan Spector has made the longest journey of the group, making the 5,600 mile trip to Mexico City for a vital 2010 FIFA World Cup qualifier.
The Americans, who finished as runners-up at the FIFA Confederations Cup in June, sit second in the CONCACAF Round 4 table, two points behind leaders Costa Rica.
Victory at the Azteca Stadium would take the US seven points clear of the fourth-placed Mexicans with four matches remaining.
The top three sides in the six-team group - also containing El Salvador, Honduras and Trinidad and Tobago - qualify automatically for next summer's finals in South Africa, with the fourth-placed team taking on the fifth-placed finisher in the South American qualifying group.
Robert Green, Matthew Upson and Carlton Cole are all with England, who take on the Netherlands in a friendly international at the Amsterdam ArenA.
Green and Cole could both be in line to start at the home of Ajax, earning their fifth and third senior caps respectively.
Fabio Capello's men will be looking for their first win over the Dutch since former Hammer Teddy Sheringham and Alan Shearer fired England to a 4-1 victory at the 1996 UEFA European Championship finals at Wembley.
Since then, England have failed to win on four consecutive occasions, drawing 1-1 at the Amsterdam ArenA on their most recent meeting in November 2006.
Further afield, Hammers trio James Collins, Danny Gabbidon and Jack Collison will all hope to be part of John Toshack's starting eleven in Montenegro.
The Welsh will be eager to extend their winning streak to three matches in the friendly in Podgorica, having overcome Estonia and Azerbaijan at the end of the 2008/09 season.
Toshack's side will use Wednesday's friendly to prepare for their vital 2010 FIFA World Cup qualifier against Russia in Cardiff on 9 September.
The seventh West Ham player to be involved in international friendly action is Herita Ilunga.
The left-back has joined up with the DR Congo squad to face Senegal in the French town of Blois, 115 miles west of Paris.
Three younger members of the West Ham squad could also be in international action on Wednesday evening.
Defender Holmar Orn Eyjolfsson and goalkeeper Marek Stech could face one another when Iceland take on Czech Republic in a friendly Under-21 match in Reykjavik.
Finally, youth team midfielder Georg Grasser will be part of the Austria U20 squad for a friendly international with Switzerland in Stegersbach.