Noble was part of the last West Ham team to record a victory at Old Trafford back in May 2007 when Carlos Tevez scored the famous goal to keep the Hammers in the Premier League.
It was a day that the experienced midfielder will never forget and hopes for similar celebrations if the Hammers can make it through to the semi-final stage.
Slaven Bilic has confirmed that he will make a few changes for the game, but is still taking the competition seriously and would love to see his side win major silverware this season.
Noble says there is no better venue to showcase your talents and hopes his side can build on the 1-1 draw with United last Sunday and make it through to the last four of the competition.
Noble said: “The Premier League is important to us because of the position we find ourselves in and we need the points. We have tough games coming up against Arsenal and Liverpool.
“But we can now look forward to a big game in the Cup against Manchester United once again and going to play at Old Trafford is everyone's dream so we hope for another good result.”
Noble insists his team-mates can take a number of positives from the draw against United last Sunday and hopes it will in their favour when they face Jose Mourinho's side once again.
We can now look forward to a big game in the Cup against Manchester United once again and going to play at Old Trafford is everyone's dream so we hope for another good result.
Noble added “It was a tough game on Sunday, especially after we took the lead so early on. We knew they were going to come at us and they did during the opening 45 minutes.
“But in the second half I thought it was more even and both teams had chances to win the game.
“Sometimes you just need that bit of luck and Darren made some great saves for us. I thought the defence played really well and we were really resilient as a team.
“You need that when you come to a place like Old Trafford and it is a special place to play but I thought we matched them man for man.”
Tickets are still available for the game on Wednesday night. Fans should visit the ticketing and membership services office at Old Trafford which is open from 8am on Wednesday.