When West Ham United take to the Boleyn Ground pitch on Saturday afternoon the men in Claret and Blue will be looking for their second consecutive win in the Barclays Premier League.
Here, whufc.com takes a look at six memorable home wins against the Saints.
West Ham United 4-1 Southampton
20 October 2012
Mark Noble scored twice to continue the Hammers' fine start to life back in the Premier League against fellow new boys Southampton.
After a forgettable 45 minutes, the home side sprung into life early in the second with goals from Noble and captain Kevin Nolan putting them two goals to the good with just three minutes of the second period played.
Adam Lallana pulled one back for the visitors with a superb half-volley but the hosts pulled clear through a Noble penalty and Modibo Maiga's fine solo effort.
West Ham United 3-0 Southampton
5 May 2001
The Hammers made sure of their Premier League status with a comfortable win over the top-ten Saints at the Boleyn Ground in 2001.
In the penultimate game of the season it was goals from Joe Cole, Frederic Kanoute and Paolo Di Canio that propelled the home team to three points.
West Ham rounded off the season with an away defeat to Middlesbrough meaning they finished the season in 15th place in the table.
Joe Cole scores the opening goal against the Saints in 2001
West Ham United 2-0 Southampton
8 March 2000
West Ham and Southampton met at the Boleyn Ground only four games after the Saints had recorded a 2-1 triumph in the reverse fixture at St Mary's.
Frank Lampard had netted in that defeat, but on this occasion Trevor Sinclair and Paulo Wanchope stepped up with the telling contributions in a solid home win.
The result took the Hammers up to ninth, the position they would end the season in, six places above the Saints.
West Ham United 3-1 Southampton
6 December 1986
A 4-0 defeat to Newcastle United seven days earlier had put a dampener on the Hammers' fine start to the season, but they were soon back to winning ways against Southampton.
The Hammers moved up to fifth with this win which came courtesy of Alan Devonshire, Paul Ince and a Tony Cottee penalty in front of just over 18,000 fans in east London.
This success turned out to be the last of the year and West Ham faded somewhat in 1987, going onto finish the season in 15th place, three places below the south coast outfit.
Alan Devonshire during his time with the Hammers
West Ham United 4-2 Southampton
22 September 1981
The Hammers extended their superb unbeaten start to the 1981/82 season to six games after edging a six-goal thriller against the Saints.
Paul Goddard stole the show with a superb hat-trick while Geoff Pike bagged the other as a confident performance ensured victory was had at the Boleyn Ground.
John Lyall's team went on to stretch their unbeaten run to nine games, before eventually suffering a 3-2 defeat to Aston Villa.
West Ham United 4-1 Southampton
12 April 1974
This meeting between the two sides was significant in deciding which of them would face relegation from Division One.
It what was expected to be a tight affair, the Hammers threw caution to the wind and racked up four goals thanks to a brace each from Clyde Best and Bryan Robson.
The Saints ended up occupying the final relegation place at seasons end having accumulated 36 points, just one less than the Hammers in 18th had accrued.