West Ham United's London 2012 Olympic representatives will both play for a place in the quarter-finals on Wednesday evening.
James Tomkins and Mohamed Diame go into the final round of Group A fixtures knowing positive results will take them through to the last eight.
Tomkins' Team GB know a draw with Uruguay will be enough, while Diame's Senegal need to better Uruguay's result in their final game against United Arab Emirates to definitely make it through. Senegal would also reach the quarter-finals should they and Uruguay both be victorious, but that combination of results would put Team GB out of the tournament.
Team GB and Senegal drew 1-1 in their opening match - a game that saw Diame captain his country but Tomkins left on the substitutes bench. Tomkins was called into the starting XI by coach Stuart Pearce for the second round of fixtures and was rewarded as Team GB beat United Arab Emirates 3-1. Diame kept his place, meanwhile, as Senegal defeated Uruguay 2-0.
Both final-round fixtures kick-off at 7.45pm, with Team GB facing Uruguay at the Millennium Stadium in Cardiff and Senegal taking on United Arab Emirates at the City of Coventry Stadium.
Mexico or South Korea, who play their final Group B matches against Switzerland and Gabon respectively on Wednesday afternoon, are likely to form the opposition should Team GB and Senegal advance.
Brazil, Belarus, Japan and Honduras look most likely to be the four other nations to qualify for the quarter-finals.