Pablo Barrera played for 75 minutes as Mexico lost 2-1 at home to Ecuador in an international friendly played in Guadalajara on Saturday night.
The Hammers forward was named in a strong starting lineup that also boasted Fulham's Carlos Salcido, Manchester United's Javier Hernandez, Tottenham Hotspur's Giovani dos Santos and Arsenal's Carlos Vela. Ecuador proved too strong though and won through Cristian Benitez's double in the first and 58th minutes.
Mexico's consolation came via a Luis Checa own goal five minutes before half-time but the North Americans were unable to find an equaliser against their visitors from South America. Barrera could be back in action on Tuesday when Mexico welcome Colombia to Monterrey on Tuesday.
Before then, Herita Ilunga's DR Congo will play host to Senegal in the country's opening 2012 CAF Africa Cup of Nations Group E qualifier in Lumbumbashi on Sunday. DR Congo will also face Cameroon and Mauritius in qualifying.
England pair Matthew Upson and Carlton Cole will travel to Switzerland for the UEFA Euro 2012 qualifier in Basel on Tuesday night. Neither featured in the 18-man matchday squad when the Three Lions defeated Bulgaria 4-0 at Wembley on Friday night. Valon Behrami is not with the Swiss as he focuses on a club playing return.