Chelsea are up next for the Hammers but Kieron Dyer is confident his team-mates old and new have what it takes to test the champions.
While the prospect of facing Carlo Ancelotti's in-form side is not the most comforting for some, the England midfielder pointed to the fact that West Ham could and perhaps should have beaten the Blues at home last season.
"We believe we can beat Chelsea," he said. "It's a completely different game. It's a derby game and form will go out of the window. We'll have the crowd and it's one of those games where Scotty [Parker] gets in the tackles and gets the crowd going, so it's going to be a completely different challenge to Man United so who knows?
"The manager is trying to change the mentality of players and we have to change it because, like I said, we have to start winning games. We're obviously playing catch-up already."
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The midfielder's return to fitness and form at the start of the 2010/11 campaign, has seen him look dangerous in his recent starts against Bolton Wanderers and Manchester United.
While things have not gone to plan on the pitch so far this term, the No7 has been grateful for the unwavering support shown by the club's supporters - in particular the 1,100 who sang their hearts out at Old Trafford last weekend.
"We were losing 2-0 to Bolton when I came off and they gave me a standing ovation and that meant a lot to me. Again, even though we were losing 3-0 they were out-singing the Man United fans and pretending to celebrate a goal being scored. That's just how they are - they are a different gear and my message to them is 'We will start winning eventually and we'll get up that league table'."
Dyer believes that there is too much talent in Avram Grant's squad for their recent struggles to continue - and new recruits like Lars Jacobsen, Thomas Hitzlsperger and Victor Obinna who have yet to play will only help the cause.
"We were disappointed again [at Old Trafford] on Saturday. I thought we were fairly comfortable before their first goal. Once Man United are 1-0 up there, it's a hard challenge.
"Man United away is not going to determine how our season goes, but it's another 3-0 loss. It would have been good to get some kind of result just to get the confidence up.
"Obviously last season was a massive struggle but where I'm coming from, for me personally, I'm just buzzing to play football again.
"We've got two weeks now and they've got to get the confidence from somewhere because when we do click and we do get it together, we are not a bad team."
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