Alex Dyer's reserves will head to Arsenal on Tuesday afternoon in confident mood after three wins out of three in the Barclays Premier Reserve League this season.
The 100 per cent Hammers will take on an Arsenal side who sit one place and one point above them in second spot of the Southern section, although the Gunners have played a game more. Dyer's young side - skippered by Jordan Spence - have already beaten Everton and Liverpool away, either side of a home victory against Wigan Athletic.
Benni McCarthy could once again lead the visitors' attack in the behind closed doors match at the Gunners' training ground after three goals in his last three starts for the second string, while the likes of Marek Stech, Julien Faubert, James Tomkins and Junior Stanislas may also get valuable playing time.
Dyer said: "It would be great to keep the unbeaten run going. It will be tough, Arsenal are a good footballing side at every level. The boys are confident and hopefully the senior players who need games will come with the same positive attitude they have shown in all the other games this season. They have been a credit.
"We are building a squad mentality and everyone is up for it when they play for the reserves. They know they can't do their chances any harm if they play well. There are a lot of first-team games between now and Christmas for them to be involved in."
The Barclays Premier Reserve League has been reshaped for the new season, with the 16 competing teams now split into three divisions.
West Ham are in the Southern section alongside Arsenal, Aston Villa, Chelsea, West Bromwich Albion and Wolverhampton Wanderers, with the Hammers taking on each of their division rivals home and away.
Dyer's squad will also take on the ten teams in the two other divisions - Northern A and Northern B - once each, making for a 20-match season. Aston Villa are currently on top of the Southern section, two points ahead of the Hammers but have played three more games.