West Ham United will play host to AFC Wimbledon or Aldershot Town in the FA Youth Cup third round.
The draw will see the Hammers face the winner of a second-round meeting which will take place next Wednesday 17 November.
AFC Wimbledon have already won four ties to reach the second-round stage, getting a walkover against Hendon, winning 1-0 at Thamesmead Town, defeating Wealdstone by the same scoreline and 2-1 at Dartford in the first-round proper. Aldershot, meanwhile, won 3-2 at Cirencester Town in their own first-round tie.
AFC Wimbledon's youth team compete in the Football Conference Youth Alliance Premier Division and go into this weekend third in the table. Aldershot's youngsters sit fifth in the Football League Youth Alliance South East Conference.
West Ham have won the FA Youth Cup on three previous occasions, lifting the trophy in 1963, 1981 and 1999.
The Hammers, who were the first club drawn out of the hat, reached the fifth round last season, defeating Plymouth Argyle and Queens Park Rangers before being defeated by Newcastle United at the Boleyn Ground.
In this year's competition, holders Chelsea begin their defence with a trip to Sunderland, while 2010 runners-up Aston Villa visit Bristol Rovers.
Full FA Youth Cup third-round draw -
(Ties to be played on or before Saturday 11 December 2010)
West Ham United v AFC Wimbledon or Aldershot Town
Blackburn Rovers v Reading
Doncaster Rovers v Middlesbrough
Dulwich Hamlet or Yeovil Town v Newcastle United
Port Vale or Grimsby Town v Burnley
Watford v Swindon Town or Coventry Sphinx
Leicester City v Macclesfield Town or Hartlepool United
Sunderland AFC v Chelsea
Arsenal v Huddersfield Town or Darlington
Oldham Athletic or Sheffield Wednesday v Manchester City
Brighton & Hove Albion or Torquay United v Derby County
Notts County or Shrewsbury Town v Liverpool
Barnsley v Tottenham Hotspur
Bristol City v Birmingham City
Bristol Rovers v Aston Villa
Wigan Athletic v Stoke City
Millwall v Walsall
Queens Park Rangers v Nottingham Forest
Bolton Wanderers v Tranmere Rovers or Crewe Alexandra
Fulham v West Bromwich Albion
Leeds United AFC v Scunthorpe United
Norwich City v Charlton Athletic or Bury Town
Hull City v Rushden & Diamonds or Wycombe Wanderers
Southend United or Brentford v Coventry City
Everton v Wolverhampton Wanderers
Blackpool v Cambridge United or Exeter City
Preston North End v Swansea City
Cardiff City v Crystal Palace
Woking or Cheltenham Town v Sheffield United
Bradford City v Southampton
Manchester United v Portsmouth
Ipswich Town v Peterborough United or Stratford Town