Tickets details for the FA Youth Cup game with Queens Park Rangers on Tuesday 19 January have been confirmed.
Adult tickets will cost £3 and juniors £1, with all tickets being sold from the cash turnstiles on the night of the match. Entrance to the Boleyn Ground will be through the West Stand lower only.
The Hammers won through to the last-32 for the first time since 2006 by beating Plymouth Argyle 1-0 after extra time last month. Republic of Ireland Under-17 forward Danny Purdy emerged from the substitutes' bench to fire home the vital goal after 104 minutes.
Under-18 captain Jordan Brown is determined to build on the strong showing in the third round on what will be the first outing at the Boleyn Ground for most of the youngsters.
"Beating Plymouth was a big confidence boost. For the last two seasons we have gone out in the first round so everyone was up for it. You could tell from the celebrations in the changing rooms afterwards that everyone was buzzing," he said.
"I didn't mind who we got in the next round but I'm glad we got a home tie."
West Ham have won the FA Youth Cup three times since its inception in 1953, lifting the trophy in 1963, 1981 and 1999, when the Hammers secured a record 9-0 aggregative victory over Coventry City in the final.
QPR, who have never reached the final of the competition, reached the fourth round courtesy of a 3-1 home victory over Southampton on Tuesday 8 December.
The match will kick-off at 7pm with cash turnstiles opening an hour before kick-off. Fans are advised to arrive in plenty of time to get tickets before the start of the game.