Two of West Ham United's band of loanees made their Football League debuts on Saturday afternoon.
Holmar Orn Eyjolfsson made a fine debut for Cheltenham Town, helping the Robins to a 1-1 draw with big-spending Notts County, while forward Anthony Edgar was wearing the colours of League Two high-fliers AFC Bournemouth for the first time.
England Under-21 striker Freddie Sears, however, was ruled out of Crystal Palace's 4-1 Championship victory over Blackpool by an ankle injury.
Spence has been in impressive form for Scunthorpe, but was an unused substitute in Saturday's 2-1 Championship defeat by Plymouth Argyle at Home Park.
In League Two, 19-year-old Eyjolfsson was named in Martin Allen's starting lineup against Notts County.
The Iceland U21 defender made his league debut at Whaddon Road, having appeared for Alex Dyer's reserve side at Portsmouth in midweek, and was given a 66-minute run out before being replaced by veteran striker Julian Alsop with Town trailing 1-0.
Lively forward Edgar, who signed his first professional contract in the summer after coming through the Academy ranks, completed a full 90 minutes for top-of-the-table
Bournemouth at Port Vale.
Edgar, who has been with the Hammers since the age of nine and still lives within walking distance of the Boleyn Ground, was also making his league debut on Saturday and did well at both ends of the pitch.
The versatile 19-year-old has followed in the footsteps of cousin Jermain Defoe, who scored 19 goals in 31 appearances for the Dorset club during the 2000/01 season.
Bournemouth are two points clear at the top of League Two, while Cheltenham are 12th.
Edgar could be back in action again on Tuesday evening when Bournemouth travel to Northampton Town in the Johnstone's Paint Trophy.