Centre half is a particular difficulty, with Christian Dailly, Andy Melville, Malky Mackay, and Calum Davenport all ruled out, but Luke says:
"We have got such a good strong squad here I am sure the lads that come in will do a great job - we have enough players to go there and get a result."
With Matthew Etherington missing, Sergei Rebrov is likely to start on the other flank to Luke, who says:
"Serge has done brilliantly in training and I am sure he will put in a great performance and get a goal.
"He is one of the best finishers I have ever seen; when he gets a chance he has got a great strike and I am sure once he gets going he will score lots of goals and do very well."
Luke is well aware of the importance of the game and adds:
"It is a massive match and it would be great to go there and get three points with them being one place above us in the league.
"They have got a strong team and are doing well after not the best of starts."
West Ham will take 3,100 fans across London for the first game between the teams since April in the 1995/96 season.
A QPR side that included Andy Impey and Trevor Sinclair won 3-0 - and were relegated by five o'clock.
"I have been there a couple of times and it is a great atmosphere so I think everyone is really looking forward to playing there," he says.
"I think even the new stadia generate a great atmosphere but at Loftus Road it is really tight and it is always a good game there."
Luke says he is fresh after a fortnight without a game, and adds:
"The lads have gone off on internationals and the lads that have stayed here have had a nice break from games.
"I feel fine and I can't wait to get going again - and I hope to score soon myself."