Steve, who has a knee problem, has missed out on returning to action, while Edouard serves a one match ban for collecting five yellow cards this season.
Furthermore, Don Hutchison, who has been out with knee ligament damage for nine months, is not yet considered ready for the first team.
Glenn has said he would be "taking a liberty" if he asked Don to go on the bench after such a lengthy absence. In the end, it is one he has decided against.
But, whoever he selects, he is insisting on a high tempo performance.
"We have got to attack the game and be very positive right from kick off to put Southampton under as much pressure as we can," he says.
"They are in fine form and we accept that. They have just beaten the champions Arsenal, who had a great win in Rome midweek, which shows you the magnitude of Southampton's win.
"They scored from three set plays against the Arsenal, so they are obviously very strong in that department, but it is up to us to impose ourselves on the game."
Glenn says that it is dog eat dog in the Premiership now, but his opposite number Gordon Strachan has said there is too much talk of Glenn's future.
He took over from Stuart Gray in the immediate aftermath of last season's victory over the Saints, and Glenn says: "Gordon has his concerns for his own team and we all know what we are going in for when we take these positions."
Squad: James, Van der Gouw, Repka, Dailly, Schemmel, Winterburn, Sinclair, Cole, Di Canio, Kanoute, Defoe, Pearce, Breen, Garcia, Sofiane, Minto, Carrick, Camara.