League leaders Liverpool come to town on Saturday when West Ham United host Brendan Rodgers' team in the Barclays Premier League on Sunday.
The Merseysiders moved to the top of the table last weekend thanks to a thumping 4-0 victory against Tottenham Hotspur which put them in pole position in the title race.
With the Reds looking to stake a step closer to becoming champions on Sunday, the Hammers will be looking to record their second consecutive home win.
Here, whufc.com takes a look at six memorable home triumphs against the Anfield outfit.
West Ham United 3-1 Liverpool
27 February 2011
The Hammers made a storming start, overwhelming their visitors before the break and taking a crucial 2-0 lead inside the opening 45 minutes. Scott Parker opened the scoring with 22 minutes on the clock, playing intricate one-twos with both Thomas Hitzlsperger and Lars Jacobsen before poking an inch-perfect shot into the bottom left hand corner of the net.
It got better the for Hammers before half-time when Demba Ba flicked Robert Green's long kick out wide to Gary O'Neil before bursting into the box and heading his cross beyond Pepe Reina.
Former Hammer Glen Johnson pulled one back for the away side six minutes from time, knocking home after Luis Suarez's low cross deflected off James Tomkins and into his path. But West Ham did not crumble and secured the points in stoppage time through Carlton Cole, who outmuscled Martin Skrtel and beat Jamie Carragher before finishing emphatically.
West Ham United 1-0 Liverpool
30 January 2008
Mark Noble held his nerve to fire in a last-gasp penalty that gave West Ham United a richly-deserved victory and ended a seven-match losing streak against Liverpool.
Jamie Carragher's added-time foul on Freddie Ljungberg gave the England U21 midfielder the chance to seal a dramatic late victory and he made no mistake to earn the Hammers first win against the Reds in eleven matches.
The Hammers had been good value for the win and could have triumphed more comfortably had Xabi Alonso's header found the back of the net instead of crashing against his own crossbar.
Liverpool players can only watch as Noble slots home the winning goal
West Ham United 1-0 Liverpool
27 November 1999
The Boleyn Ground continued to be a fortress for Harry Redknapp's Hammers as they saw off Liverpool in 1999.
Home fans had seen only one defeat from eleven matches in all competitions and they were left to celebrate another win thanks to Trevor Sinclair's goal.
The win avenged defeat to the Reds just a month earlier at Anfield when the Merseysiders had won by the same score line.
West Ham United 3-0 Liverpool
10 May 1995
West Ham produced a terrific home display to comfortably dispatch Liverpool in the penultimate match of the 1994/95 season.
The Hammers spent the whole of the season in the bottom half of the table while their opponents mounted a top four assault, making this result even more pleasing for the Boleyn Ground faithful.
Victory was secured courtesy of a brace from Don Hutchinson and Matt Holmes' one and only goal of the season.
Hutchison celebrates scoring for the Hammers during his second spell at the Club
West Ham United 4-1 Liverpool
League Cup Round Four
30 November 1988
This crushing win was a rare highlight in a season which promised much but ultimately delivered very little for the Hammers.
Future Reds captain Paul Ince scored twice and Tony Gale once, with Steve Staunton putting through his own goal as West Ham progressed to the next round.
The Hammers reached the semi-finals before losing out to Luton Town over two legs. Liverpool exacted revenge for their big defeat at the Boleyn Ground by relegating West Ham on the final day of the season with a 5-1 win at Anfield.
West Ham United 7-0 Liverpool
1 September 1930
West Ham's biggest ever win against Liverpool came back in 1930, and was inspired by Victor Watson who tore the Reds to shreds.
The front man scored four times as the home side ran riot in front of just over 11,000 people at the Boleyn Ground.
Stanley Earle netted twice and Wilf James chipped in with a goal to complete the rout.